Mark Guiltinan, Ph.D.

Mark Guiltinan, Ph.D.

  • J. Franklin Styer Professor of Horticultural Botany and Professor of Plant Molecular Biology
422 Life Sciences Bldg.
University Park, PA 16802

Areas of Expertise

  • Plant Genomics and Genetics
  • Plant Molecular Biology
  • Theobroma cacao (cocoa)

Education

  • PhD., Biology, University of California, Irvine, 1986
  • B.S., Botany, Humboldt State University, 1978

Vitae

Teaching

Independent Undergraduate Research - HORT/BIOL 496

 

Publications

Gene Expression Modularity Reveals Footprints of Polygenic Adaptation in Theobroma cacao.
Molecular biology and evolution, Hämälä, T, Guiltinan, Mark, Marden, James, Maximova, Siela, dePamphilis, Claude, Tiffin, P, 2020

Metabolomic profile of cacao cell suspensions growing in blue light/dark conditions with potential in food biotechnology
Plant Cell, Tissue and Organ Culture, Gallego, Adriana M., Rojas, Luisa F., Rodriguez, Héctor A., Mora, Conrado, Atehortúa, Lucía, Urrea, Aura I., Guiltinan, Mark, Maximova, Siela, Gaquerel, Emmanuel, Zuluaga, Martha, Pabón-Mora, Natalia, 2019

Resistant and susceptible cacao genotypes exhibit defense gene polymorphism and unique early responses to Phytophthora megakarya inoculation
Plant molecular biology, Pokou, Désiré N., Fister, Andrew S., Winters, Noah, Tahi, Mathias, Klotioloma, Coulibaly, Sebastian, Aswathy, Marden, James Harold, Maximova, Siela, Guiltinan, Mark, 2019

Widely distributed variation in tolerance to Phytophthora palmivora in four genetic groups of cacao
TREE GENETICS & GENOMES, Fister, Andrew, Leandro-Munoz, Mariela, Zhang, Dapeng, Marden, James, Tiffin, Peter, dePamphilis, Claude, Maximova, Siela, Guiltinan, Mark, 2019

Transcriptomic analyses of cacao cell suspensions in light and dark provide target genes for controlled flavonoid production
Scientific reports, Gallego, Adriana M., Rojas, Luisa F., Parra, Oriana, Rodriguez, Héctor A., Mazo Rivas, Juan C., Urrea, Aura Inés, Atehortúa, Lucía, Fister, Andrew S., Guiltinan, Mark, Maximova, Siela, Pabón-Mora, Natalia, 2018

Transient expression of CRISPR/Cas9 machinery targeting TcNPR3 enhances defense response in theobroma cacao
Frontiers in Plant Science, Fister, Andrew S., Landherr, Lena, Maximova, Siela N., Guiltinan, Mark J., 2018

Gallego AM, Rojas LF, Parra O, Rodriguez HA, Mazo Rivas JC, Urrea AI, Atehortúa L, Fister AS, Guiltinan MJ, Maximova SN et al: Transcriptomic analyses of cacao cell suspensions in light and dark provide target genes for controlled flavonoid production. 2018, 8(1):13575. Open Access Link
Scientific Reports, Guiltinan, Mark, 2018

Pervasive effects of a dominant foliar endophytic fungus on host genetic and phenotypic expression in a tropical tree (reprint)
Recent Advances in Symbiosis Research: Integrative Approaches, Mejía, LC, Herre, EA, Sparks, JP, Winter, K, García, MN, Van Bael, SA, Stitt, Joseph, Shi, Z, Zhang, Y, Guiltinan, Mark, Maximova, SN, 2017

Phytophthora megakarya and Phytophthora palmivora, Closely Related Causal Agents of Cacao Black Pod Rot, Underwent Increases in Genome Sizes and Gene Numbers by Different Mechanisms
Genome Biology and Evolution, Ali, Shahin, Shao, Jonathan, Lary, David, Kronmiller, Brent, Shen, Danyu, Strem, Mary, Amoako-Attah, Ishmael, Akrofi, Andrew, Begoude, B., ten Hoopen, G., Coulibaly, Klotioloma, Kebe, Boubacar, Melnick, Rachel, Guiltinan, Mark, Tyler, Brett, Meinhardt, Lyndel, Bailey, Bryan, 2017

Protocol
Plant Methods, Fister, Andrew S., Shi, Zi, Zhang, Yufan, Helliwell, Emily E., Maximova, Siela N., Guiltinan, Mark J., 2016

Enhanced resistance in Theobroma cacao against oomycete and fungal pathogens by secretion of phosphatidylinositol-3-phosphate-binding proteins
Plant Biotechnology Journal, Helliwell, Emily E., Vega-Arreguín, Julio, Shi, Zi, Bailey, Bryan, Xiao, Shunyuan, Maximova, Siela, Tyler, Brett M., Guiltinan, Mark, 2016

Tc-MYBPA an Arabidopsis TT2-like transcription factor and functions in the regulation of proanthocyanidin synthesis in Theobroma cacao
BMC Plant Biology, Liu, Yi, Shi, Zi, Maximova, Siela, Payne, Mark J., Guiltinan, Mark, 2015

Enhanced somatic embryogenesis in Theobroma cacao using the homologous BABY BOOM transcription factor
BMC plant biology, Florez, Sergio L., Erwin, Rachel L., Maximova, Siela N., Guiltinan, Mark J., Curtis, Wayne R., 2015

Proteome analysis during pod, zygotic and somatic embryo maturation of Theobroma cacao
Journal of Plant Physiology, Niemenak, Nicolas, Kaiser, Edward, Maximova, Siela, Laremore, Tatiana Nikolaevna, Guiltinan, Mark, 2015

Characterization of a stearoyl-acyl carrier protein desaturase gene family from chocolate tree, theobroma cacao L
Frontiers in Plant Science, Zhang, Yufan, Maximova, Siela N., Guiltinan, Mark J., 2015

Enhanced resistance in Theobroma cacao against oomycete and fungal pathogens by secretion of phosphatidylinositol-3-phosphate-binding proteins
Plant Biotechnol J, Helliwell, E., Vega-Arreguin, J., Shi, Z., Bailey, B., Xiao, S., Maximova, Siela, Tyler, B., Guiltinan, Mark, 2015

Applications of Genomics to the Improvement of Cacao
CHOCOLATE AND HEALTH: CHEMISTRY, NUTRITION AND THERAPY, Guiltinan, Mark, Maximova, Siela, 2015

Yield Performance and Bean Quality Traits of Cacao Propagated by Grafting and Somatic Embryo-derived Cuttings
HORTSCIENCE, Goenaga, Ricardo, Guiltinan, Mark, Maximova, Siela, Seguine, Ed, Irizarry, Heber, 2015

Genome and secretome analysis of the hemibiotrophic fungal pathogen, Moniliophthora roreri, which causes frosty pod rot disease of cacao: Mechanisms of the biotrophic and necrotrophic phases
BMC genomics, Meinhardt, Lyndel W., Costa, Gustavo Gilson L., Thomazella, Daniela P.T., Teixeira, Paulo José P.L., Carazzolle, Marcelo F., Schuster, Stephan C., Carlson, John E., Guiltinan, Mark J., Mieczkowski, Piotr, Farmer, Andrew, Ramaraj, Thiruvarangan, Crozier, Jayne, Davis, Robert E., Shao, Jonathan, Melnick, Rachel L., Pereira, Gonçalo A.G., Bailey, Bryan A., 2014

Pervasive effects of a dominant foliar endophytic fungus on host genetic and phenotypic expression in a tropical tree
Frontiers in Microbiology, Mejía, Luis C., Herre, Edward A., Sparks, Jed P., Winter, Klaus, García, Milton N., Van Bael, Sunshine A., Stitt, Joseph, Shi, Zi, Zhang, Yufan, Guiltinan, Mark J., Maximova, Siela N., 2014

TcNPR3 from Theobroma cacao functions as a repressor of the pathogen defense response
BMC plant biology, Shi, Zi, Zhang, Yufan, Maximova, Siela N., Guiltinan, Mark J., 2013

Proanthocyanidin synthesis in Theobroma cacao: Genes encoding anthocyanidin synthase, anthocyanidin reductase, and leucoanthocyanidin reductase
BMC plant biology, Liu, Yi, Shi, Zi, Maximova, Siela, Payne, Mark J., Guiltinan, Mark J., 2013

The salicylic acid receptor NPR3 is a negative regulator of the transcriptional defense response during early flower development in Arabidopsis
Molecular plant, Shi, Zi, Maximova, Siela, Liu, Yi, Verica, Joseph, Guiltinan, Mark J., 2013

Biodegradable polyphosphazenes containing antibiotics
Polymer Chemistry, Tian, Zhicheng, Zhang, Yufan, Liu, Xiao, Chen, Chen, Guiltinan, Mark, Allcock, Harry R., 2013

Dynamic changes in pod and fungal physiology associated with the shift from biotrophy to necrotrophy during the infection of Theobroma cacao by Moniliophthora roreri
Physiological and Molecular Plant Pathology, Bailey, Bryan A., Crozier, Jayne, Sicher, Richard C., Strem, Mary D., Melnick, Rachel, Carazzolle, Marcelo F., Costa, Gustavo G.L., Pereira, Gonçalo A.G., Zhang, Dapeng, Maximova, Siela, Guiltinan, Mark, Meinhardt, Lyndel, 2013

The mitochondrial genome of Moniliophthora roreri, the frosty pod rot pathogen of cacao
Fungal Biology, Costa, Gustavo G.L., Cabrera, Odalys G., Tiburcio, Ricardo A., Medrano, Francisco J., Carazzolle, Marcelo F., Thomazella, Daniela P.T., Schuster, Stephen C., Carlson, John Edward, Guiltinan, Mark, Bailey, Bryan A., Mieczkowski, Piotr, Pereira, Gonçalo A.G., Meinhardt, Lyndel W., 2012

Starch-branching enzyme IIa is required for proper diurnal cycling of starch in leaves of maize
Plant physiology, Yandeau-Nelson, Marna D., Laurens, Lieve, Shi, Zi, Xia, Huan, Smith, Alison M., Guiltinan, Mark J., 2011

Deficiency of maize starch-branching enzyme i results in altered starch fine structure, decreased digestibility and reduced coleoptile growth during germination
BMC plant biology, Xia, Huan, Yandeau-Nelson, Marna, Thompson, Donald B., Guiltinan, Mark J., 2011

The genome of Theobroma cacao
Nature Genetics, Argout, Xavier, Salse, Jerome, Aury, Jean Marc, Guiltinan, Mark, Droc, Gaetan, Gouzy, Jerome, Allegre, Mathilde, Chaparro, Cristian, Legavre, Thierry, Maximova, Siela, Abrouk, Michael, Murat, Florent, Fouet, Olivier, Poulain, Julie, Ruiz, Manuel, Roguet, Yolande, Rodier-Goud, Maguy, Barbosa-Neto, Jose Fernandes, Sabot, Francois, Kudrna, Dave, Ammiraju, Jetty Siva S., Schuster, Stephan C., Carlson, John Edward, Sallet, Erika, Schiex, Thomas, Dievart, Anne, Kramer, Melissa, Gelley, Laura, Shi, Zi, Bérard, Aurélie, Viot, Christopher, Boccara, Michel, Risterucci, Ange Marie, Guignon, Valentin, Sabau, Xavier, Axtell, Michael, Ma, Zhaorong, Zhang, Yufan, Brown, Spencer, Bourge, Mickael, Golser, Wolfgang, Song, Xiang, Clement, Didier, Rivallan, Ronan, Tahi, Mathias, Akaza, Joseph Moroh, Pitollat, Bertrand, Gramacho, Karina, D'Hont, Anglique, Brunel, Dominique, Infante, Diogenes, Kebe, Ismael, Costet, Pierre, Wing, Rod, McCombie, W. Richard, Guiderdoni, Emmanuel, Quetier, Francis, Panaud, Olivier, Wincker, Patrick, Bocs, Stephanie, Lanaud, Claire, 2011

(*These authors contributed equally to this work) The genome of Theobroma cacao
Nature Genetics, *Argout, X, None, *Salse, J, None, *Aury, J, None, Guiltinan, Mark, Droc, G, Gouzy, J, Allegre, M, Chaparro, C, Legavre, T, Maximova, Siela, Abrouk, M, Murat, F, Fouet, O, Poulain, J, Ruiz, M, Roguet, Y, Rodier-Goud, M, Barbosa-Neto, J, Sabot, F, Kudrna, D, Ammiraju, J, Schuster, Stephan, Carlson, John, Sallet, E, Schiex, T, Dievart, A, Kramer, M, Gelley, L, Shi, Z, Bérard, A, Viot, C, Boccara, M, Risterucci, A, Guignon, V, Sabau, X, Axtell, Michael, Ma, Z, Zhang, Y, Brown, S, Bourge, M, Golser, W, Song, X, Clement, D, Rivallan, R, Tahi, M, Akaza, J, Pitollat, B, Gramacho, K, D’Hont, A, Brunel, D, Infante, D, Kebe, I, Costet, P, Wing, R, McCombie, W, Guiderdoni, E, Quetier, F, Panaud, O, Wincker, P, Sidibe-Bocs, S, Lanaud, C, 2011

Population structure and molecular characterization of nigerian field genebank collections of cacao, theobroma cacaol
Silvae Genetica, Aikpokpodion, P. O., Kolesnikova-Allen, M., Adetimirin, V. O., Guiltinan, Mark, Eskes, A. B., Motamayor, J. C., Schnell, R. J., 2010

Functional analysis of the theobroma cacao NPR1 gene in arabidopsis
BMC Plant Biology, Shi, Zi, Maximova, Siela, Liu, Yi, Verica, Joseph, Guiltinan, Mark, 2010

Functional genomics of cacao
Advances in Botanical Research, Micheli, Fabienne, Guiltinan, Mark, Gramacho, Karina Peres, Wilkinson, Mike J., Figueira, Antonio Vargas de Oliveira, Cascardo, Júlio Cézar de Mattos, Maximova, Siela, Lanaud, Claire, 2010

Genes acquired by horizontal transfer are potentially involved in the evolution of phytopathogenicity in Moniliophthora perniciosa and Moniliophthora roreri, two of the major pathogens of cacao.
Journal of molecular evolution, Tiburcio, R, Costa, G, Carazzolle, M, Mondego, J, Schuster, Stephan, Carlson, John, Guiltinan, Mark, Bailey, B, Mieczkowski, P, Meinhardt, L, Pereira, G, 2010

Seed color as an indicator of flavanol content in Theobroma cacao L
Chocolate, fast foods and sweeteners: consumption and health. Nova Science Pub. Inc, New York, Cakirer, Melis, Ziegler, Gregory, Guiltinan, Mark, 2010