Mark Guiltinan, Ph.D.

The cacao gene atlas: a transcriptome developmental atlas reveals highly tissue-specific and dynamically-regulated gene networks in Theobroma cacao L
BMC Plant Biology, Kulesza, Evelyn, Thomas, Patrick, Prewitt, Sarah F., Shalit-Kaneh, Akiva, Wafula, Eric, Knollenberg, Benjamin, Winters, Noah, Esteban, Eddi, Pasha, Asher, Provart, Nicholas, Praul, Craig, Landherr, Lena, dePamphilis, Claude, Maximova, Siela N., Guiltinan, Mark J., 2024

Accumulation of cadmium in soils, litter and leaves in cacao farms in the North Sierra Nevada de Santa Marta, Colombia
Geoderma Regional, Guarín, Daniel, Martín-López, Javier, Libohova, Zamir, Benavides-Bolaños, Jhony, Maximova, Siela N., Guiltinan, Mark J., Spargo, John, da Silva, Mayesse, Fernandez, Alejandro, Drohan, Patrick, 2024

A combination of conserved and diverged responses underlies Theobroma cacao’s defense response to Phytophthora palmivora
BMC Biology, Winters, N, Wafula, E, Knollenberg, B, Hämälä, T, Timilsena, P, Perryman, M, Zhang, D, Sheaffer, L, Praul, C, Ralph, P, Prewitt, S, Leandro-Muñoz, M, Delgadillo-Duran, D, Altman, N, Tiffin, P, Maximova, Siela, dePamphilis, Claude W., Marden, James H., Guiltinan, Mark J., 2024

Cadmium contamination in cacao farms of Piura, North Peru: A comprehensive assessment of geogenic and anthropogenic sources and implications for future production
Environmental Challenges, Guarín, Daniel, Hamamura, Nadia, Cortez, Jesús, Benavides, Jhony, Spargo, John, Guiltinan, Mark, Maximova, Siela, Otilia Acha de la Cruz, None, de la Cruz, Otilia, Drohan, Patrick, 2023

Inter-species functional compatibility of the Theobroma cacao and Arabidopsis FT orthologs: 90 million years of functional conservation of meristem identity genes
BMC Plant Biology, Prewitt, S. F., Shalit-Kaneh, A., Maximova, S. N., Guiltinan, M. J., 2021

Transcriptomic analyses of cacao flavonoids produced in photobioreactors
BMC Genomics, Gallego, Adriana M., Rojas, Luisa F., Valencia, Wilmar G., Atehortúa, Lucía, Urrea, Aura I., Fister, Andrew S., Guiltinan, Mark J., Maximova, Siela, Pabón-Mora, Natalia, 2021

Genomic structural variants constrain and facilitate adaptation in natural populations of Theobroma cacao, the chocolate tree
Proceedings of the National Academy of Sciences of the United States of America, Hämälä, Tuomas, Wafula, Eric K., Guiltinan, Mark J., Ralph, Paula E., dePamphilis, Claude W., Tiffin, Peter, 2021

Cadmium phytoextraction by Helianthus annuus (sunflower), Brassica napus cv Wichita (rapeseed), and Chyrsopogon zizanioides (vetiver)
Chemosphere, Benavides, Jhony, Benavides, Bolaños, Drohan, Patrick, Spargo, J. T., Maximova, S. N., Guiltinan, M. J., Miller, Douglas, 2021

Widely distributed variation in tolerance to Phytophthora palmivora in four genetic groups of cacao
Tree Genetics and Genomes, Fister, Andrew, Leandro-Muñoz, Mariela, Zhang, Dapeng, Marden, James H., Tiffin, Peter, dePamphilis, Claude, Maximova, Siela, Guiltinan, Mark J., 2020

Gene Expression Modularity Reveals Footprints of Polygenic Adaptation in Theobroma cacao
Molecular Biology and Evolution, Hämälä, Tuomas, Guiltinan, Mark J., Marden, James H., Maximova, Siela N., dePamphilis, Claude, Tiffin, Peter, 2020

Clovamide, a Hydroxycinnamic Acid Amide, Is a Resistance Factor Against Phytophthora spp. in Theobroma cacao
Frontiers in Plant Science, Knollenberg, Benjamin, Li, Guo-Xing, Lambert, Joshua D., Maximova, Siela N., Guiltinan, Mark J., 2020

Metabolomic profile of cacao cell suspensions growing in blue light/dark conditions with potential in food biotechnology
Plant Cell, Tissue and Organ Culture, Gallego, Adriana M., Rojas, Luisa F., Rodriguez, Héctor A., Mora, Conrado, Atehortúa, Lucía, Urrea, Aura I., Guiltinan, Mark J., Maximova, Siela N., Gaquerel, Emmanuel, Zuluaga, Martha, Pabón-Mora, Natalia, 2019

Resistant and susceptible cacao genotypes exhibit defense gene polymorphism and unique early responses to Phytophthora megakarya inoculation
Plant Molecular Biology, Pokou, Désiré N., Fister, Andrew S., Winters, Noah, Tahi, Mathias, Klotioloma, Coulibaly, Sebastian, Aswathy, Marden, James H., Maximova, Siela N., Guiltinan, Mark J., 2019

Transcriptomic analyses of cacao cell suspensions in light and dark provide target genes for controlled flavonoid production
Scientific Reports, Gallego, Adriana M., Rojas, Luisa F., Parra, Oriana, Rodriguez, Héctor A., Mazo Rivas, Juan C., Urrea, Aura Inés, Atehortúa, Lucía, Fister, Andrew S., Guiltinan, Mark J., Maximova, Siela N., Pabón-Mora, Natalia, 2018

Glucocorticoid receptor-regulated TcLEC2 expression triggers somatic embryogenesis in Theobroma cacao leaf tissue
PLoS One, Fister, Andrew S., Landherr, Lena, Perryman, Melanie, Zhang, Yufan, Guiltinan, Mark J., Maximova, Siela N., 2018

The potential of somatic embryogenesis for commercial-scale propagation of elite cacao varieties., Maximova, Siela, Guiltinan, M, 2018

Transient expression of CRISPR/Cas9 machinery targeting TcNPR3 enhances defense response in theobroma cacao
Frontiers in Plant Science, Fister, Andrew S., Landherr, Lena, Maximova, Siela N., Guiltinan, Mark J., 2018

Gallego AM, Rojas LF, Parra O, Rodriguez HA, Mazo Rivas JC, Urrea AI, Atehortúa L, Fister AS, Guiltinan MJ, Maximova SN et al: Transcriptomic analyses of cacao cell suspensions in light and dark provide target genes for controlled flavonoid production. 2018, 8(1):13575. Open Access Link
Scientific Reports, Guiltinan, Mark, 2018

Transient Introduction of CRISPR/Cas9 Machinery Targeting TcNPR3 Enhances Defense Response in Theobroma cacao
Plant Biotechnology (in press), Fister, A., Sheaffer, L, Maximova, S, Guiltinan, Mark, 2018

Phytophthora megakarya and Phytophthora palmivora, Closely Related Causal Agents of Cacao Black Pod Rot, Underwent Increases in Genome Sizes and Gene Numbers by DifferentMechanisms
Genome Biology and Evolution, Ali, Shahin S., Shao, Jonathan, Lary, David J., Kronmiller, Brent A., Shen, Danyu, Strem, Mary D., Amoako-Attah, Ishmael, Akrofi, Andrew Yaw, Begoude, B. A.Didier, ten Hoopen, G. Martijn, Coulibaly, Klotioloma, Kebe, Boubacar Ismaël, Melnick, Rachel L., Guiltinan, Mark J., Tyler, Brett M., Meinhardt, Lyndel W., Bailey, Bryan A., 2017

Theobroma cacao L. pathogenesis-related gene tandem array members show diverse expression dynamics in response to pathogen colonization
BMC Genomics, Fister, Andrew S., Mejia, Luis C., Zhang, Yufan, Herre, Edward Allen, Maximova, Siela N., Guiltinan, Mark J., 2016

Protocol: Transient expression system for functional genomics in the tropical tree Theobroma cacao L.
Plant Methods, Fister, Andrew S., Shi, Zi, Zhang, Yufan, Helliwell, Emily E., Maximova, Siela N., Guiltinan, Mark J., 2016

Enhanced resistance in Theobroma cacao against oomycete and fungal pathogens by secretion of phosphatidylinositol-3-phosphate-binding proteins
Plant Biotechnology Journal, Helliwell, Emily E., Vega-Arreguín, Julio, Shi, Zi, Bailey, Bryan, Xiao, Shunyuan, Maximova, Siela N., Tyler, Brett M., Guiltinan, Mark J., 2016

Tc-MYBPA is an Arabidopsis TT2-like transcription factor and functions in the regulation of proanthocyanidin synthesis in Theobroma cacao
BMC Plant Biology, Liu, Yi, Shi, Zi, Maximova, Siela N., Payne, Mark J., Guiltinan, Mark J., 2015

Enhanced somatic embryogenesis in Theobroma cacao using the homologous BABY BOOM transcription factor
BMC Plant Biology, Florez, Sergio L., Erwin, Rachel L., Maximova, Siela N., Guiltinan, Mark J., Curtis, Wayne R., 2015

Proteome analysis during pod, zygotic and somatic embryo maturation of Theobroma cacao
Z. PFLANZENPHYSIOL., Niemenak, Nicolas, Kaiser, Edward, Maximova, Siela N., Laremore, Tatiana, Guiltinan, Mark J., 2015

Characterization of a stearoyl-acyl carrier protein desaturase gene family from chocolate tree, theobroma cacao L
Frontiers in Plant Science, Zhang, Yufan, Maximova, Siela N., Guiltinan, Mark J., 2015

Yield performance and bean quality traits of cacao propagated by grafting and somatic embryo-derived cuttings
Hortscience: A Publication of the American Society for Hortcultural Science, Goenaga, Ricardo, Guiltinan, Mark, Maximova, Siela, Seguine, Ed, Irizarry, Heber, 2015

Application of glycerol as a foliar spray activates the defence response and enhances disease resistance of Theobroma cacao
Molecular Plant Pathology, Zhang, Yufan, Smith, Philip, Maximova, Siela N., Guiltinan, Mark J., 2015

Two Theobroma cacao genotypes with contrasting pathogen tolerance show aberrant transcriptional and ROS responses after salicylic acid treatment
Journal of Experimental Botany, Fister, Andrew S., O'Neil, Shawn T., Shi, Zi, Zhang, Yufan, Tyler, Brett M., Guiltinan, Mark J., Maximova, Siela N., 2015

Enhanced resistance in Theobroma cacao against oomycete and fungal pathogens by secretion of phosphatidylinositol-3-phosphate-binding proteins
Plant Biotechnol J, Helliwell, E., Vega-Arreguin, J., Shi, Z., Bailey, B., Xiao, S., Maximova, S, Tyler, B., Guiltinan, Mark, 2015

Applications of Genomics to the Improvement of Cacao, Guiltinan, Mark, Maximova, S, 2015

Genome-wide analysis reveals divergent patterns of gene expression during zygotic and somatic embryo maturation of Theobroma cacao L., the chocolate tree
BMC Plant Biology, Maximova, Siela N., Florez, Sergio, Shen, Xiangling, Niemenak, Nicolas, Zhang, Yufan, Curtis, Wayne, Guiltinan, Mark J., 2014

The Theobroma cacao B3 domain transcription factor TcLEC2 plays a duel role in control of embryo development and maturation
BMC Plant Biology, Zhang, Yufan, Clemens, Adam, Maximova, Siela N., Guiltinan, Mark J., 2014

Genome and secretome analysis of the hemibiotrophic fungal pathogen, Moniliophthora roreri, which causes frosty pod rot disease of cacao: Mechanisms of the biotrophic and necrotrophic phases
BMC Genomics, Meinhardt, Lyndel W., Costa, Gustavo Gilson L., Thomazella, Daniela P.T., Teixeira, Paulo José P.L., Carazzolle, Marcelo F., Schuster, Stephan C., Carlson, John E., Guiltinan, Mark J., Mieczkowski, Piotr, Farmer, Andrew, Ramaraj, Thiruvarangan, Crozier, Jayne, Davis, Robert E., Shao, Jonathan, Melnick, Rachel L., Pereira, Gonçalo A.G., Bailey, Bryan A., 2014

Pervasive effects of a dominant foliar endophytic fungus on host genetic and phenotypic expression in a tropical tree
Frontiers in Microbiology, Mejía, Luis C., Herre, Edward A., Sparks, Jed P., Winter, Klaus, García, Milton N., Van Bael, Sunshine A., Stitt, Joseph, Shi, Zi, Zhang, Yufan, Guiltinan, Mark J., Maximova, Siela N., 2014